Thrombophilia & blood clots.
An increased tendency to form clots — when it needs testing, when it doesn't, and how it's managed.
What is thrombophilia?
Thrombophilia is an increased tendency to form blood clots. It can be inherited (present from birth) or acquired later in life. Clots most commonly form in the deep veins of the legs (deep vein thrombosis, or DVT) and can travel to the lungs (pulmonary embolism, or PE).
Having a thrombophilia does not mean a clot is inevitable — many people with one never have a clot. Assessment is about understanding your individual risk and whether it changes how you should be managed.
Important: a suspected clot can be a medical emergency. Sudden breathlessness, chest pain, or a painful, swollen leg should be assessed urgently — contact your doctor, call 000, or go to your nearest emergency department.
Inherited and acquired causes
- Inherited — such as Factor V Leiden, the prothrombin gene variant, or deficiencies of protein C, protein S or antithrombin
- Acquired — most importantly antiphospholipid syndrome, an autoimmune clotting condition
- Situational — surgery, immobility, long travel, pregnancy, the contraceptive pill or hormone therapy, and some medical conditions all add temporary risk
Who should be tested
Thrombophilia testing is not recommended for everyone, and testing at the wrong time or in the wrong person can be misleading. It is most useful when the result would actually change management — for example decisions about how long to continue blood thinners, or planning around pregnancy.
We can advise whether testing is worthwhile in your situation, and interpret results in the context of your personal and family history rather than in isolation.
How clots are managed
Treatment of a clot usually involves anticoagulation (blood-thinning medication). Key decisions include which medication to use and how long to continue it, balancing the risk of another clot against the risk of bleeding. We also help with prevention around higher-risk times such as surgery or pregnancy.
When to see a haematologist
Frequently asked
Ask your GP for a referral, or contact our rooms to discuss assessment and management in Footscray.
This page provides general information only and is not a substitute for individual medical advice. It should not be used to diagnose or treat a health problem. Please speak with your GP or haematologist about your own circumstances. Last reviewed August 2026.